Guanosine-3',5'-bisdiphosphate

• Description:

  (p)ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria[1]. During nutritional starvation (p)ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p)ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA). Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival[2].

• Synonyms:

  (ppGpp)

• UNSPSC:

  12352208

• UNSPSC Description:

  Nucleic acids

• HS Code:

  29349990

• eClass Number:

  34160990

• eClass Product Group:

  Nucleinsäure nicht klassifiziert

• Concentration:

  100 mM

• Purity:

  ≥ 95 % (HPLC)

• Form:

  Solution in water

• pH:

  7.5 ±0.5

• Color:

  Colorless to slightly yellow

• Autoclavability:

  false

• Smiles:

  [nH]1c(N)nc2n([C@H]3[C@H](O)[C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)O)OP(=O)(O)OP(=O)(O)O)cnc2c1=O

• Shipping Conditions:

  Shipped on gel packs

• Storage Conditions:

  Store at -20 °C Short term exposure up to 1 week cumulative to ambient temperature possible.

• Shelf Life:

  12 months after date of delivery