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Anti-Kv3.3

CAT: 0171-Y059824Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0171-Y059824Size:50 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KNC3 Kv3.3 is a member of the Shaw type family of voltage-gated K+ channels that includes four members (Kv3.1-3.4). Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.3 is mostly localized in the brain, although it has been observed in vascular smooth muscle cells and eye epithelium. In the brain its expression pattern largely overlaps that of the Kv3.1 channel suggesting that they may form functional heteromers. Indeed, mouse knockouts of both Kv3.1 and Kv3.3, but not either channel alone, display severe motor defects.
CAS Number
9007-83-4
Reactivity
Rat
Immunogen
Peptide KSPITPGSRGRYSRDRAC corresponding to residues 701-718 of rat Kv3.3 (Accession number Q01956).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC
Concentration
1ug/ul
Purity
Affinity purified on immobilized antigen.
Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Specificity
Recognizes only splice variant Kv3.3
Applications Notes
Western Blotting: Rat brain membrane (1:200). Immunohistochemistry: Rat brain sections.

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