Anti Human DUSP6 Polyclonal

CAT: 0171-Y054549Size: 100 µLDry Ice: NoHazardous: No
CAT#:0171-Y054549Size:100 µL
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Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
Recombinant Protein
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,ELISA
Concentration
1ug/ul
Purity
Antigen Affinity Purified
Buffer
PBS, pH 7.4 with 0.1% sodium azide, 50% Glycerol
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Applications Notes
ELISA 1:1,000~100,000 Western blotting 1:100~1,000

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