Anti-Smad7

• Description:

  The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  Rabbit polyclonal Smad7 antibody was raised against a peptide near intermediate residues of human Smad7 protein.

• Clonality:

  Polyclonal

• Type:

  Antibodies-Polyclonal

• Applications:

  WB,IHC,ELISA

• Concentration:

  100ug/100ul

• Purity:

  Affinity purified

• Buffer:

  PBS, pH 7.4 with 0.02% Sodium Azide

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment:

  IgG

• Applications Notes:

  For research use only Peptide ELISA titer: 1:5,000-1:20,000 Western blot analysis: 1:500-1:1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use.

• CAS Number:

  9007-83-4