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Anti-Smad7

CAT: 0171-Y058362Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0171-Y058362Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
Rabbit polyclonal Smad7 antibody was raised against a peptide near intermediate residues of human Smad7 protein.
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC,ELISA
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Applications Notes
For research use only Peptide ELISA titer: 1:5,000-1:20,000 Western blot analysis: 1:500-1:1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use.

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