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Anti-RAR alpha

CAT: 0171-Y058256Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0171-Y058256Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
Rabbit polyclonalRAR alpha (1) antibody was raised against a 15 amino acid peptide from near the C terminal residues of human retinoic acid receptor alpha protein.
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC,ELISA
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Applications Notes
For research use only Peptide ELISA titer: 1:40,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use.

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