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Anti- p21

CAT: 0171-Y058132Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0171-Y058132Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Synthetic peptide conjugated to KLH
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC,ELISA
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
Rabbit IgG
Specificity
Not yet tested in other species.
Applications Notes
For research use only Peptide ELISA titer: 1:20,000-1ï¼?0,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use.

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