Anti-MiTF

• Description:

  The Microphthalmia-associated transcription factor or MiTF is encoded by the MITF gene. This transcription factor has a critical role in neural crest development and differentiation of neural crest derivatives. It is a transcription factor for tyrosinase and tyrosinase-related protein 1 and plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. The MITF gene is important as it regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Diseases such as Waardenburg syndrome type 2 and Tietz syndrome are associated with heterozygous mutations in this gene.

• Reactivity:

  Human

• Immunogen:

  Recombinant protein corresponding to human MiTF.

• Clonality:

  Monoclonal

• Type:

  Antibodies-Monoclonal

• Applications:

  WB,IP

• Concentration:

  100µg/100µl

• Purity:

  The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.

• Buffer:

  PBS, pH 7.4 with 0.05% sodium azide

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment:

  IgG2b

• Specificity:

  Human MiTF.

• Applications Notes:

  WB: 1:250~1:1000. IP: Use at an assay dependent concentration. Optimal dilutions should be calculated by the end user based on their specific application.

• CAS Number:

  9007-83-4