Anti-MEK3

CAT: 0171-Y058147Size: 100 µLDry Ice: NoHazardous: No
CAT#:0171-Y058147Size:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide conjugated to KLH
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC,ELISA
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
Rabbit IgG
Specificity
Not yet tested in other species
Applications Notes
For research use only Peptide ELISA titer: 1:20,000-80,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:200-400 Optimal dilutions/concentrations should be determined by the end use.

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