Anti-MBD2

• Description:

  DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  Synthetic peptide conjugated to KLH

• Clonality:

  Polyclonal

• Type:

  Antibodies-Polyclonal

• Applications:

  WB,ELISA

• Concentration:

  100ug/100ul

• Purity:

  Affinity purified

• Buffer:

  PBS, pH 7.4 with 0.02% Sodium Azide

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment:

  Rabbit IgG

• Specificity:

  Not yet tested in other species.

• Applications Notes:

  For research use only Peptide ELISA titer: 1:40,000-1:80,000 Western blot analysis: 1:200-500 Optimal dilutions/concentrations should be determined by the end use

• CAS Number:

  9007-83-4