Anti-F10

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]

9007-83-4

Human

Rabbit polyclonal F10 (1) antibody was raised against a recombinated human F10 protein 314-485aa (BC046125).

Polyclonal

Antibodies-Polyclonal

WB,IHC,ELISA

100ug/100ul

Affinity purified

PBS, pH 7.4 with 0.02% Sodium Azide

Ice Pack