Anti-Cyclin D1

• Description:

  The DMITF1 encodes a transcription factor that contains a cyclin-D binding domain. Expression of this gene is frequently reduced in 40% of human non-small-cell lung carcinomas due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. The Cyclin D1 is induced by the oncogenic Ras signalling pathway and functions as a tumor suppressor by activating the transcription of ARF to arrest cell growth or induce apoptosis. Other diseases related with the DMITF1 gene include parathyroid adenomas and mantle-cell lymphoma (MCL). The Anti-Cyclin D1 Antibody is a useful tool in cancer research particularly in studying oncogenesis.

• Reactivity:

  Human

• Immunogen:

  Recombinant protein corresponding to human Cyclin D1

• Clonality:

  Monoclonal

• Type:

  Antibodies-Monoclonal

• Applications:

  WB,IHC,IP

• Concentration:

  100µg/100µl

• Purity:

  The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.

• Buffer:

  PBS, pH 7.4 with 0.05% sodium azide

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment:

  IgG2a

• Specificity:

  Anti-Cyclin D1 Antibody recognizes human Cyclin D1

• Applications Notes:

  WB: 1:10000~1:50000; IP: 1:30; IHC: 1:100~1:500. Optimal dilutions should be calculated by the end user based on their specific application.

• CAS Number:

  9007-83-4