Anti-BRCA1

• Description :

  BRCA1 is a nuclear phosphoprotein that plays a role in maintaining genomic stability. As a tumor suppressor, BRCA1 combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 associates with RNA polymerase II through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Other diseases associated with BRCA1 include primary peritoneal carcinoma.

• CAS Number :

  9007-83-4

• Reactivity :

  Human

• Immunogen :

  A synthetic peptide corresponding to a sequence in the human BRCA1

• Clonality :

  Monoclonal

• Type :

  Antibodies-Monoclonal

• Applications :

  WB,IHC,IP,ICC/IF

• Concentration :

  100µg/100µl

• Purity :

  The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.

• Buffer :

  PBS, pH 7.4 with 0.05% sodium azide

• Shipping Conditions :

  Ice Pack

• Storage Conditions :

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment :

  IgG1

• Specificity :

  Human BRCA1

• Applications Notes :

  WB: 1:2000~1:5000 IHC: 1:200~1:500 IF: 1:200~1:500 Optimal dilutions should be calculated by the end user based on their specific application.