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Anti-AKT1

CAT: 0171-Y058027Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0171-Y058027Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
Synthetic peptide conjugated to KLH
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,ELISA,ICC/IF
Concentration
100ug/100ul
Purity
Protein A purified
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
Rabbit IgG
Specificity
AKT1 antibody detects endogenous levels of AKT1 protein. Not tested with other proteins
Applications Notes
Recommended dilutions Peptide ELISA: 1:32,000 WB: 1/500 - 1/1000 IF:1:50-100. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user

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