Anti-β-Catenin

CAT: 0171-Y300107Size: 100 µLDry Ice: NoHazardous: No
CAT#:0171-Y300107Size:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Catenin is a part of a complex of proteins that constitute adherens junctions (AJs), which are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. It is also the key downstream component of the canonical Wnt signaling pathway. β-Catenin anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. It binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Other diseases associated with CTNNB1 include Colorectal Adenomatous Polyposis, Autosomal Recessive, With Pilomatricomas and Mental Retardation, Autosomal Dominant 19.
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Purified recombinant full length human β-Catenin expressed in E. coli
Clonality
Monoclonal
Type
Antibodies-Monoclonal
Applications
WB,IHC,ELISA,ICC/IF
Concentration
100µg/100µl
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG1
Specificity
Human β-Catenin
Applications Notes
WB: 1:2000~1:5000 ELISA: 1:1000~1:5000 IHC: 1:200~1:500 IF: 1:200~1:500 Optimal dilutions should be calculated by the end user based on their specific application.

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