Anti-TYK2 (Ab-1054)

• Description:

  This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  The antiserum was produced against synthesized non-phosphopeptide derived from human TYK2 around the phosphorylation site of tyrosine 1054 (H-E-YP-Y-R).

• Clonality:

  Polyclonal

• Type:

  Antibodies-Polyclonal

• Applications:

  IHC

• Concentration:

  1ug/ul

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Buffer:

  phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Specificity:

  TYK2 (Ab-1054) antibody detects endogenous levels of TYK2 protein around tyrosine 1054.

• Applications Notes:

  IHC: 1:50~1:100

• CAS Number:

  9007-83-4