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Anti-MAD2(L1)

CAT: 0171-Y120003Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Y120003Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mad2 provides feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Researchers have found that deletion of a single Mad2 allele results in a defective mitotic checkpoint; Mad2+/- mice develop lung tumors at high rates after long latencies, implicating defects in the mitotic checkpoint of tumorigenesis . Mad2 is an important target in cancer research because it may sensitize cells to existing chemotherapeutics and its expression may be an indicator of cellular sensitivity to chemotherapy.
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Recombinant human Mad2
Clonality
Monoclonal
Clone
KD6.17D10.2G9
Type
Antibodies-Monoclonal
Applications
WB,IP
Concentration
100ug/100ul
Purity
Purified ascites.
Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG1
Specificity
Western blot with a variety of human cell lines confirms that the antibody is specific for human Mad2; other species specificity has not yet been determined.
Applications Notes
Titrate for optimal dilution for your application.

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