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Anti-CD3

CAT: 0171-Y059047Size: 100 µgDry Ice: NoHazardous: No
CAT#:0171-Y059047Size:100 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD3 complex is crucial in transducing antigen-recognition signals into the cytopasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Human thymocytes and T lymphocytes
Clonality
Monoclonal
Type
Antibodies-Monoclonal
Applications
IP,Flow cyt,Other
Concentration
1ug/ul
Purity
Affinity purified
Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG2a
Specificity
The antibody reacts with gamma epsilon and delta epsilon dimers of human CD3 complex, a part of a bigger multisubunit complex of the T cell receptor (CD3/TCR) expressed on peripheral blood T lymphocytes and mature thymocytes. It reacts strongly with gamma delta T lymphocytes.
Applications Notes
- Flow Cytometry 1:500 (Positive control: Peripheral Blood Lymphocytes, JURKAT human leukemia T cell line) - Immunoprecipitation: The antibody immunoprecipitates from a detergent lysate of surface-radioiodinated T cells a strong zone of about 22 kDa and a weak 28-kDa zone, which is typical pattern yielded by a reference antibody Leu-4. - Functional Application: The antibody has strong mitogenic effect on peripheral T lymphocytes; it reacts strongly with gamma delta T lymphocytes.

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