Recombinant Mouse KGF (FGF7)

Recombinant Mouse KGF (FGF7)

• Description: KGF is a member of the family of fibroblast growth factors, it is secreted in large amounts by fibroblast- like stromal cells in epithelial tissues. The KGF receptor encodes a tyrosine kinase and is a member of the family of receptors binding aFGF and bFGF. Binding of KGF to its receptor is competed by aFGF and bFGF. Although KGF is a potent specific mitogen for many epithelial cells it is not so for fibroblasts and endothelial cells. KGF is thought to play an important role in the paracrine growth control of normal epithelial cells. KGF stimulates the proliferation of primary and secondary human keratinocytes to the same extent as EGF.
• CAS Number: 9000-83-3
• Gene Name: FGF7
• Gene Aliases: KGF, Fibroblast growth factor 7, FGF-7, Heparin-binding growth factor 7, HBGF-7
  Recombinant Mouse Keratinocyte Growth Factor (FGF7)
• Gene ID: 14178
• Accession Number: P36363
• Organism: Mouse
• Source: E. coli
• Concentration: <1.0 EU/μg of recombinant protein as determined by the LAL method.
• Purity: >95% as determined by SDS-PAGE
• Solubility: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Function: The ED(50) was determined by the dose-dependent proliferation of Immortalized Human Bronchial Epithelial Cells-SV40 and was found to be &lt;0.05ng/mL.
• Molecular Weight: 19
• Shipping Conditions: Ambient Temperature
• Storage Conditions: The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
• Appearance: Lyophilized Powder
• Formulation: Lyophilized from a 0.2 μm filtered solution in PBS