Recombinant Mouse CCL22

Recombinant Mouse CCL22

• Description: CCL22 was described initially as a constitutively produced, thymus-specific chemokine, implicated in the recruitment of T cells. One of the functions of CCL22 originally described was induction of migration of CCR4+ Th2 cells, but it has additionally been shown to regulate migration of Tregs. CCL22 has been implicated in a number of diseases, including allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Similarly, a presumed role for CCR4+ cells has been suggested for endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes
• CAS Number: 9000-83-3
• Gene Name: CCL22
• Gene Aliases: C-C motif chemokine 22, Activated B and dendritic cell-derived, CC chemokine ABCD-1, Small-inducible cytokine A22, Abcd1, Scya22
  Recombinant Mouse Macrophage-Derived Chemokine (CCL22)
• Gene ID: 20299
• Accession Number: O88430
• Organism: Mouse
• Source: E. coli
• Concentration: <1.0 EU/μg of recombinant protein as determined by the LAL method.
• Purity: >95% as determined by SDS-PAGE
• Solubility: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Function: Determined by its ability to chemoattract human T cells using a concentration range of 10-50 ng/mL.
• Molecular Weight: 8
• Shipping Conditions: Ambient Temperature
• Storage Conditions: Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.
• Appearance: Lyophilized Powder
• Formulation: Recombinant mouse CCL22 is presented as 0.2 μm filtered PBS pH 7.5.