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Recombinant Human TNFRSF10B

CAT: 0171-Z102249Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0171-Z102249Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNFRSF10B is a member of the TNFR superfamily and is a cell surface receptor that is involved in apoptosis. It contains an intracellular death domain and can be activated by binding to either membrane-anchored or soluble TRAIL/Apo2L. Diseases associated with TNFRSF10B include squamous cell carcinoma, head and neck and oral cavity cancer. Among its related pathways are Akt Signaling and Akt Signaling. It is closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity.
CAS Number
9000-83-3
Gene Name
TNFRSF10B
Gene Aliases
Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TRAIL receptor 2, TRAIL-R2, CD262, TNF-related apoptosis-inducing ligand receptor 2
Gene ID
8795
Accession Number
O14763
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL.
Molecular Weight
15
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a solution in PBS (pH 7.4) with 5% Mannitol, 5% Trehalose and 0.02% Tween 80.

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