Recombinant Human RANTES (CCL5)
CAT:
171-Z100785
Size:
20 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human RANTES (CCL5)
- Description: RANTES belongs to the family of chemotactic cytokines known as chemokines and is expressed by an early response gene. The synthesis of RANTES is induced by TNF-alpha and IL-1-alpha. RANTES is chemotactic for T cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. RANTES also activates eosinophils to release eosinophilic cationic protein while being a potent activator of oxidative metabolism specific for eosinophils. RANTES increases the adherence of monocytes to endothelial cells and selectively supports the migration of monocytes and T lymphocytes expressing the cell surface markers CD4 and UCHL1.
- CAS Number: 9000-83-3
- Gene Name: CCL5
- Gene Aliases: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta, C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, TCP228, T-cell-specific protein RANTES, D17S136E, SCYA5
- Gene ID: 6352
- Accession Number: P13501
- Organism: Human
- Source: E. coli
- Concentration: <1.0 EU/μg of recombinant protein as determined by the LAL method
- Purity: >95% as determined by SDS-PAGE
- Solubility: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
- Function: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/mL.
- Molecular Weight: 9
- Shipping Conditions: Ambient Temperature
- Storage Conditions: The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
- Appearance: Lyophilized Powder
- Formulation: Lyophilized from a 0.2 μm filtered solution in PBS