Recombinant Human PTH

• Description :

  Parathyroid hormone is a circulating hormone that acts as the central regulator of calcium metabolism by directly targeting bone, kidney, and intestine. The classical concept of PTH action is that it regulates serum calcium levels by stimulating bone resorption. However, intermittent administration of PTH selectively stimulates bone formation. It is now known that PTH binds to its receptor PTH1R, and activates the G protein alpha subunits. Besides PKA and PKC activation, PTH also regulates MAPKs including p42/p44 ERKs, p38, and c-Jun N-terminal kinase subtypes.

• CAS Number :

  9000-83-3

• Gene Name :

  PTH

• Gene Aliases :

  PTH, Parathormone, Parathyrin
  Recombinant Human Parathyroid Hormone (PTH)

• Gene ID :

  5741

• Accession Number :

  P01270

• Organism :

  Human

• Source :

  E. coli

• Concentration :

  <1.0 EU/μg of recombinant protein as determined by the LAL method

• Purity :

  >95% as determined by SDS-PAGE

• Solubility :

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function :

  The ED(50) was determined by the dose-dependent proliferation of Immortalized Human Osteoblasts- SV40 and was found to be <0.5ng/mL.

• Molecular Weight :

  9

• Shipping Conditions :

  Ambient Temperature

• Appearance :

  Lyophilized Powder

• Formulation :

  Lyophilized from a 0.2 μm filtered solution in PBS