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Recombinant Human Noggin (NOG)

CAT: 0171-Z100929Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0171-Z100929Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Noggin is a secreted homodimeric glycoprotein that binds to ligands of the TGF-beta family (BMPs) and regulates their activity by inhibiting their access to signaling receptors. Mature human Noggin protein contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine knot structure. Noggin binds different BMPs with variable affinities, antagonizing specific BMPs during skeletal development. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin.
CAS Number
9000-83-3
Gene Name
NOG
Gene Aliases
NOG
Gene ID
9241
Accession Number
Q13253
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in 10mM AcOH (acetic Acid) to a concentration not less than 0.1-1.0 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by induced alkaline phosphatase secretion in ATDC cells and was determined to be ≤ 20 ng/mL, corresponding to a specific activity of ≥ 5.0 x 10^5 units/mg.
Molecular Weight
23
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2μm filtered solution in 30% CH3CN, 0.1% TFA

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