Recombinant Human MIG (CXCL9)

• Description:

  MIG (CXCL9) protein belongs to the family of chemotactic cytokines known as chemokines. The synthesis of MIG is specifically induced in macrophages and in other cells by IFN-gamma.Human neutrophils produce mig in response to IFN-gamma in combination with either TNF-alpha or bacterial lipopolysaccharides and this response is blocked by IL-10 and IL-4. MIG is a chemoattractant for stimulated but not resting T cells, however it is not active on neutrophils or monocytes.

• Gene Name:

  CXCL9

• Gene Aliases:

  C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, Small-inducible cytokine B9, CMK, HuMIG, SCYB9, CXCL9

• Gene ID:

  4283

• Accession Number:

  Q07325

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  <1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function:

  Determined by its ability to chemoattract human peripheral blood T lymphocytes using a concentration range of 10-80 ng/mL.

• Molecular Weight:

  11

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Recombinant MIG/CXCL9 was lyophilized from 1.0 mg/mL solution in 25 mM NaCl 10 mM PB pH 7.0.

• CAS Number:

  9000-83-3