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Recombinant Human LTA

CAT: 0171-Z100865Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0171-Z100865Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.
CAS Number
9000-83-3
Gene Name
LTA
Gene Aliases
Tumor necrosis factor ligand superfamily member 1, TNFSF1, Lymphotoxin-alpha, LT-alpha, LTA
Recombinant Human Tumor Necrosis Factor Beta (LTA)
Gene ID
4049
Accession Number
P01374
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was measured in a cytotoxicity assay using mouse L929 cells in the presence of the metabolic inhibitor actinomycin, and was determined to be less than 0.1 ng/mL.
Molecular Weight
19
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
TNF-beta is presented as a 0.2 μm filtered PBS solution pH 7.5.

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