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Recombinant Human IL9

CAT: 0171-Z102475Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0171-Z102475Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin 9 (IL9) is an immunoregulatory cytokine belonging to the IL-7/IL-9 cytokine family. Commonly produced by TH17 cells, IL9 acts as a hematopoietic cell regulator by preventing apoptosis and stimulates cell proliferation of T lymphocytes, erythroid cells, and mast cells. It binds to the IL9 receptor (IL9R) to activate different signal transducer and activator (STAT) proteins. It also supports IL2 and IL4 independent growth of helper T-cells and affects TH17 and Tregs through STAT3 and STAT5 signalling activation. Furthermore, IL9 has been found to be a candidate gene for asthma as its presence determines the pathogenesis of bronchial hyper-responsiveness. Although human and mouse IL9 share a 56% amino acid identity, human IL9 is not active on mouse cells and can be found to inhibit melanoma growth in mice.
CAS Number
9000-83-3
Gene Name
IL9
Gene Aliases
P40, T-cell growth factor P40
Gene ID
3578
Accession Number
P15248
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>85% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight
14.4
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.0

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