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Recombinant Human IL8 (72aa)

CAT: 0171-Z101605Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0171-Z101605Size:25 µg
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Description
IL8 is produced by stimulated monocytes but not by tissue macrophages and T-lymphocytes. In many cell types the synthesis of IL8 is strongly stimulated by IL1, TNF-alpha and bacterial lipopolysaccharides. The expression of IL8 from resting and stimulated human blood monocytes is up-regulated by IL7. The IL8 receptor (CD128) is a dimeric glycoprotein consisting of a 59 kDa and a 67 kDa subunit. It is expressed in many different cell types including those not responding to IL8. IL8 differs from all other cytokines in its ability to specifically activate neutrophil granulocytes. IL8 also enhances the metabolism of reactive oxygen species and increases chemotaxis and the enhanced expression of adhesion molecules. Recombinant Human IL8 (72aa) represents the construct spanning residues 28 to 99, inclusive.
CAS Number
9000-83-3
Gene Name
IL8
Gene Aliases
IL-8, C-X-C motif chemokine 8, Emoctakin, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, Monocyte-derived neutrophil-activating peptide, MONAP, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, T cell chemotactic factor
Recombinant Human Interleukin-8 (72AA) (IL8)
Gene ID
3576
Accession Number
P10145
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED50 as determined by dose dependent proliferation of endothelial cells was found to be <0.5ng/ml
Molecular Weight
8.3
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.0)

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