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Recombinant Human IL33

CAT: 0171-Z100539Size: 1 mgDry Ice: NoHazardous: No
CAT#:0171-Z100539Size:1 mg
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Description
IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes. Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL- 33 produced a wide spectrum of cytokines and chemokines. In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment.
CAS Number
9000-83-3
Gene Name
IL33
Gene Aliases
IL-33, Nuclear factor from high endothelial venules, Interleukin-1 family member 11, IL1F-11, C9orf26, NF-HEV
Recombinant Human Interleukin-33 (IL33)
Gene ID
90865
Accession Number
O95760
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by the dose-dependent proliferation of murine D10S cells is ≤ 0.03 ng/mL.
Molecular Weight
18
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Recombinant Interleukin-33 was lyophilized from 0.2 μm filtered 1.0 mg/mL in PBS buffer.

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