Recombinant Human IL31

CAT: 0171-Z100525Size: 10 µgDry Ice: NoHazardous: No
CAT#:0171-Z100525Size:10 µg
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Description
IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family. The receptors for IL-6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL-31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown.
CAS Number
9000-83-3
Gene Name
IL31
Gene Aliases
IL-31
Recombinant Human Interleukin-31 (IL31)
Gene ID
386653
Accession Number
Q6EBC2
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by the ability to induce STAT3 activation in U87 MG cells, and was determined to be not less than 7.0 ng/mL.
Molecular Weight
18
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Recombinant Interleukin-31 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.

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