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Recombinant Human IL28A

CAT: 0171-Z102455Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0171-Z102455Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interferon lambda-2, also known as Interleukin 28A, is an antiviral cytokine with immunomodulatory activity and is distantly related to the IL-10 family and type I interferons. IL28A along with IL29 and IL28B, are three closely related cytokines that form a cytokine gene cluster that use a distinct receptor system which induces antiviral defence signals. IL28A interacts with a heterodimeric class II cytokine receptor ligand and leads to the activation of the JAK/STAT signalling pathway, which ultimately leads to IFN-stimulated gene (ISG) and MHC class I antigen expression. It also plays a key role in antiviral defence in Toll-like receptors (TLR) and intestinal epithelia.
CAS Number
9000-83-3
Gene Name
IFNL2
Gene Aliases
Zcyto20, Interleukin-28A, Interferon lambda-2
Gene ID
282616
Accession Number
Q8IZJ0
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED50 is 10.0-50.0 ng/mL as determined by an anti-viral assay (using human hepatocellular carcinoma cells infected with EMC virus)
Molecular Weight
19.5
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution containing no additives.

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