Recombinant Human IL20

CAT: 0171-Z101075Size: 10 µgDry Ice: NoHazardous: No
CAT#:0171-Z101075Size:10 µg
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Description
IL-19 and IL-20 are mainly produced by activated monocytes, IL-24 is produced by Th2 cells, monocytes, and melanocytic cells, and IL-22 and IL-26 are primarily produced by activated T cells. Like IL-10, these class II cytokines signal through heterodimeric receptors. Overexpression of IL-20 in transgenic mice causes neonatal death as well as skin abnormalities, including aberrant epidermal differentiation. IL-20 selectively enhances multipotential hematopoietic progenitors in vitro and in vivo. IL-20 is preferentially expressed in monocytes18 and induces STAT 3 activation through binding to two types of IL-20 receptor (R) complexes, either IL-20R1/IL-20R2 or IL-22R1/IL-20R2
CAS Number
9000-83-3
Gene Name
IL20
Gene Aliases
IL-20, Cytokine Zcyto10, ZCYTO10
Recombinant Human Interleukin-20 (IL20)
Gene ID
50604
Accession Number
Q9NYY1
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by by a cell proliferation assay using human IL-20R-alpha and human IL-20R-beta co-transfected murine BaF3 pro-B cells, and was found to be less than 0.6 ng/mL, corresponding to a specific activity of 1.7 x 10^6 IU/mg.
Molecular Weight
16
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Recombinant Human Interleukin-17 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.

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