Recombinant Human IL19

• Description:

  IL19 belongs to the IL-10 family of proinflammatory cytokines, which is composed of IL10, IL19, IL20, IL22, IL24, and IL26. IL19 is mainly expressed in monocytes and binds to the IL20 receptor complex which leads to the activation of the signal transducer and activator of transcription 3 (STAT3). It also performs up-regulation of IL6 and TNF-alpha and apoptosis induction, thus signifying its role in inflammatory responses.

• Gene Name:

  IL19

• Gene Aliases:

  Melanoma differentiation-association protein-like protein, NG.1

• Gene ID:

  29949

• Accession Number:

  Q9UHD0

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  < 1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  Reconstitute in sterile PBS at 10µg/mL (containing at least 0.1% human or bovine serum albumin)

• Function:

  The ED50 is 0.5-1.5 ng/mL as determined by a cell proliferation assay with the use of transfected BaF3 mouse pro-B cells with human IL-20Rα and human IL-20Rβ

• Molecular Weight:

  18

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from a 0.2 µm filtered solution in PBS (with BSA as a carrier protein)

• CAS Number:

  9000-83-3