Recombinant Human IL18BP

• Description :

  IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular isoforms. IL-18 binding protein is a constitutively expressed and secreted protein that resembles the extracellular domains of Ig-like receptors but has no transmembrane form. Because IL-18 is one of the early signals leading to IFN-gamma production by Th1 cells, blocking IL-18 activity by IL-18BP may be involved in down-modulation of the early phases of immune responses.

• Gene Name :

  IL18BP

• Gene Aliases :

  IL-18BP, Tadekinig-alfa
  Recombinant Human Interleukin-18 Binding Protein (IL18BP)

• Gene ID :

  10068

• Accession Number :

  O95998

• Organism :

  Human

• Source :

  HEK cells

• Concentration :

  <1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity :

  >95% as determined by SDS-PAGE

• Solubility :

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function :

  The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA.

• Molecular Weight :

  19

• Shipping Conditions :

  Ambient Temperature

• Storage Conditions :

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance :

  Lyophilized Powder

• Formulation :

  Recombinant IL-18BP is supplied as an 0.2 μm filtered PBS solution.

• CAS Number :

  9000-83-3