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Recombinant Human IL18BP

CAT: 0171-Z101045Size: 200 µgDry Ice: NoHazardous: No
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CAT#:0171-Z101045Size:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular isoforms. IL-18 binding protein is a constitutively expressed and secreted protein that resembles the extracellular domains of Ig-like receptors but has no transmembrane form. Because IL-18 is one of the early signals leading to IFN-gamma production by Th1 cells, blocking IL-18 activity by IL-18BP may be involved in down-modulation of the early phases of immune responses.
CAS Number
9000-83-3
Gene Name
IL18BP
Gene Aliases
IL-18BP, Tadekinig-alfa
Recombinant Human Interleukin-18 Binding Protein (IL18BP)
Gene ID
10068
Accession Number
O95998
Organism
Human
Source
HEK cells
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA.
Molecular Weight
19
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Recombinant IL-18BP is supplied as an 0.2 μm filtered PBS solution.

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