Recombinant Human IL16

• Description:

  Interleukin 16 (IL16) is a pleiotrophic cytokine derived from CD8+ T-cells that stimulates chemotaxis in CD4+ lymphocytes, monocytes, and eosinophils. It primes CD4+ T-cells for IL2 and IL15 responsiveness, induces T-lymphocyte Interleukin 2 (IL2) receptor expression, and inhibits HIV replication. The signalling process of IL16 is mediated by CD4, and undergoes proteolysis to yield two functional proteins. IL16 isoform 1 has the possible function of acting as a scaffolding protein to anchor ion channels in the membrane, while isoform 3 is involved in cell cycle progression in T-cells and transcriptional regulation of SKP2. IL16 mRNA expression levels have been found in various tissues such as spleen, bone marrow, thymus, and lymph nodes.

• Gene Name:

  IL16

• Gene Aliases:

  Lymphocyte chemoattractant factor

• Gene ID:

  3603

• Accession Number:

  Q14005

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  < 1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  Reconstitute in sterile PBS at 5µg/mL

• Function:

  The ED50 is 7.5-37.5 ng/mL as determined by its ability to chemoattract human CD4+ T lymphocytes (at a concentration range of 1.0-100.0 ng/mL).

• Molecular Weight:

  13.5

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from a 0.2 µm filtered solution in PBS

• CAS Number:

  9000-83-3