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Recombinant Human IFNB1

CAT: 0171-Z101489Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0171-Z101489Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IFN-beta is produced mainly by fibroblasts and some epithelial cell types. The synthesis of IFN-beta can be induced by common inducers of interferons including viruses, double-stranded RNA, and micro-organisms. It is induced also by some cytokines such as TNF and IL-1. IFN-beta binds to the same receptor as IFN-alpha. IFN-beta is involved in the regulation of unspecific humoral immune responses and immune responses against viral infections. IFN-beta increases the expression of HLA class 1 antigens and blocks the expression of HLA class 2 antigens stimulated by IFN-gamma. IFN-beta stimulates the activity of natural killer cells and hence also antibody-dependent cytotoxicity. IFN-beta shows antiproliferative activity against a number of cell lines established from solid tumors.
CAS Number
9000-83-3
Gene Name
IFNB1
Gene Aliases
IFN-beta, Immune interferon, Fibroblast interferon, Leukocyte interferon, B cell interferon, Type I interferon
Recombinant Human Interferon-Beta 1A (IFNB1)
Gene ID
3456
Accession Number
P01574
Organism
Human
Source
CHO cells
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The activity was determined by the viral resistance assay of Human WISH cells was found to be in the range of 3.0 x 10^8 IU/mg.
Molecular Weight
19
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Recombinant IFN-b 1a was lyophilized from a 0.2 μm filtered sodium acetate solution pH 4.8.

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