Recombinant Human Galectin-3 (LGALS3)

• Description:

  Gal-3 interacts, via its lectin domain, with glycoproteins and glycolipids on the surface of animal cells. It has been shown that nuclear Gal­3 can modulate gene expression while cytosolic Gal­3 can inhibit apoptosis and participate in exocytosis. Gal-3 is generally expressed by the epithelial cells of many tissues as well as by inflammatory cells. An increased level of Gal-3 expression may lead to some lymphomas, as well as thyroid and hepatic carcinomas while the down-regulation has been associated with breast and colon cancer.

• Gene Name:

  LGALS3

• Gene Aliases:

  IgE-Binding Protein, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein, GALBP, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen

• Gene ID:

  3958

• Accession Number:

  P17931

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  < 1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin

• Function:

  Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 3-10 µg/mL.

• Molecular Weight:

  26.1

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from a 0.2 μm filtered solution in PBS.

• CAS Number:

  9000-83-3