Recombinant Human FGF21

• Description:

  FGF-21 is a secreted growth factor of the FGF family, classified as an FGF-19 subfamily member. Proteins of the FGF family are known to play a central role with respect to both prenatal and postnatal growth and development, and regeneration of a variety of tissues by promoting cellular proliferation and differentiation. In the presence of beta Klotho (protein cofactor), FGF-21 signals via the FGFR receptors to stimulate insulin independent glucose uptake by adipocytes.

• Gene Name:

  FGF21

• Gene Aliases:

  FGF-21
  Recombinant Human Fibroblast Growth Factor 21 (FGF21)

• Gene ID:

  26291

• Accession Number:

  Q9NSA1

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  <1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function:

  The bioactivity was determined in a NIH/3T3 cell proliferation assay with an ED50 <1ng/ml.

• Molecular Weight:

  19.7

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2°- 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from 0.2 μm filtered solution in Tris and NaCl (pH 8.0)

• CAS Number:

  9000-83-3