Recombinant Human FGF21

• Description:

  FGF21 is a secreted growth factor of the FGF family, classified as an FGF19 subfamily member. Proteins of the FGF family are known to play a central role with respect to both prenatal and postnatal growth and development, and regeneration of a variety of tissues by promoting cellular proliferation and differentiation. In the presence of beta Klotho (protein cofactor), FGF21 signals via the FGFR receptors to stimulate insulin independent glucose uptake by adipocytes.

• Gene Name:

  FGF21

• Gene Aliases:

  FGF-21
  Recombinant Human Fibroblast Growth Factor 21 (FGF21)

• Gene ID:

  26291

• Accession Number:

  Q9NSA1

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  <1.0 EU/μg of recombinant protein as determined by the LAL method

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function:

  The bioactivity was determined in a NIH/3T3 cell proliferation assay with an ED50 <1ng/ml.

• Molecular Weight:

  19.7

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2°- 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from 0.2 μm filtered solution in Tris and NaCl (pH 8.0)

• CAS Number:

  9000-83-3