Recombinant Human BAFF-R (TNFRSF13C)
CAT:
171-Z100019
Size:
1.0 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human BAFF-R (TNFRSF13C)
- Description: The B cell-activating factor from the TNF family (BAFF), is emerging as an important regulator of B cell and T cell responses. BAFF was originally identified as a factor responsible for B cell survival and maturation. BAFF binds to several receptors. These include transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), BAFF-R (BR3), and B cell maturation Ag (BCMA). BAFF-R appears to be particularly important for the regulation of B cell survival and maturation in the spleen, because A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice.
- CAS Number: 9000-83-3
- Gene Name: TNFRSF13C
- Gene Aliases: Tumor necrosis factor receptor superfamily member 13C, TNFRSF13C, B-cell-activating factor receptor, BAFF receptor, BAFFR, BLyS receptor 3, CD_antigen=CD268
- Gene ID: 115650
- Accession Number: Q96RJ3
- Organism: Human
- Source: E. coli
- Concentration: <1.0 EU/μg of recombinant protein as determined by the LAL method.
- Purity: >95% as determined by SDS-PAGE
- Solubility: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
- Function: The ED(50) was determined by the ability to block BAFF induced survival of splenocyte cells, and was found to be in the range of 1-5 ug/mL.
- Molecular Weight: 9
- Shipping Conditions: Ambient Temperature
- Storage Conditions: The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
- Appearance: Lyophilized Powder
- Formulation: Recombinant BAFF-R was lyophilized from a 0.2 μm filtered solution in 2.5% glycine, 0.5% sucrose, 0.01% Tween80, 5 mM Glutamic acid, pH 4.5.