Rentosertib

CAT: 0804-HY-160623-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-160623-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Rentosertib (INS018 055) (compound 112) is the orally active TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively[1].

CAS Number

2828567-39-9

Product Name Alternative

INS018_055; TNIK&MAP4K4-IN-2

UNSPSC

12352005

Target

Cadherin; Interleukin Related; MAP4K; TGF-beta/Smad

Type

Reference compound

Related Pathways

Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tnik-map4k4-in-2.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN=C(C2=C(C3=CC=C(C=C3)F)N=CN2C(C)C)N1)NC4=CC=C(N5CCN(CC5)C)C=C4

Molecular Formula

C27H30FN7O

Molecular Weight

487.57

References & Citations

[1]Aleksandrs Zavoronkovs, et al. Analogs for the treatment of disease. WO2022179528A1.|[2]Ren F, et al. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol. 2025 Jan;43 (1) :63-75.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP4K4/HGK

Rentosertib

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