MA-PEG4-VC-PAB-DMEA-duocarmycin DM

MA-PEG4-VC-PAB-DMEA-duocarmycin DM

• UNSPSC Description: MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668).
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ma-peg4-vc-pab-dmea-duocarmycin-dm.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(N(CCN(C(OC2=CC3=C([C@@H](CN3C(C4=CC5=CC(OCCN(C)C)=CC=C5N4)=O)CCl)C6=CC=CC=C26)=O)C)C)=O)C=C1)=O)CCCNC(N)=O)=O)C(C)C)=O)CCN7C(C=CC7=O)=O
• Molecular Weight: 1381.96
• References & Citations: [1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-30.|[2]Italo Beria, et al. New alkylating agents. Franch, WO2013149948A1.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported