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Annonacin

CAT: 0804-HY-N2877-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2877-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways[1][2][3][4].
CAS Number
111035-65-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Calcium Channel; Na+/K+ ATPase; Potassium Channel; Sodium Channel
Type
Natural Products
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/annonacin.html
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1O[C@@H](C)C=C1C[C@H](O)CCCCC[C@@H](O)CCCC[C@@H](O)[C@@H]2O[C@@H]([C@H](O)CCCCCCCCCCCC)CC2
Molecular Formula
C35H64O7
Molecular Weight
596.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Yiallouris A, et al. Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways. Cell Death Dis. 2018 Jul 9;9 (7) :764.|[2]Yuan SS, et al. Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. Life Sci. 2003 May 9;72 (25) :2853-61.|[3]Yamada ES, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014 Mar;253:113-25. |[4]Md Roduan MR, et al. Modulation of cancer signalling pathway (s) in two -stage mouse skin tumorigenesis by annonacin. BMC Complement Altern Med. 2019 Sep 3;19 (1) :238.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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