Ethidium homodimer

CAT: 0804-HY-D0093-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-D0093-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ethidium homodimer (EthD-1) is a high-affinity fluorescent nucleic acid dye commonly used to stain mammals, bacteria, yeast, and fungi. Ethidium homodimer binds to DNA or RNA, enhancing fluorescence more than 30 times. The Ethidium homodimer has a strong positive charge, so it cannot cross cell membranes and stain living cells; But the Ethidium homodimer can cross the disordered region of the dead cell membrane to reach the nucleus and embed the DNA double strand to produce red fluorescence. Therefore, Ethidium homodimer is a relatively sensitive nucleic acid stain that can accurately detect nucleic acids in solution or in decomposing cells. Ethidium homodimer binds DNA, Ex/Em=528/617 nm[1].
CAS Number
[61926-22-5]
Product Name Alternative
EthD-1
UNSPSC
12171500
Hazard Statement
H261, H314, H351
Target
DNA Stain
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ethidium-homodimer.html
Purity
99.4
Solubility
10 mM in DMSO
Smiles
NC1=CC=C2C(C(C3=CC=CC=C3)=[N+](CCCNCCNCCC[N+]4=C(C5=CC=CC=C5)C6=CC(N)=CC=C6C7=C4C=C(N)C=C7)C8=C2C=CC(N)=C8)=C1.Cl.Cl.[Cl-].[Cl-]
Molecular Formula
C46H50Cl4N8
Molecular Weight
856.75
Precautions
H261, H314, H351
References & Citations
[1]Joshua R Edwards, et al. A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer. BMC Physiol. 2007 Feb 23;7:1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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