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SU5408

CAT: 0804-HY-103002-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103002-01Size:1 mg
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Description
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM.
CAS Number
15966-93-5
Product Name Alternative
VEGFR2 Kinase Inhibitor I
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/SU5408.html
Purity
98.0
Solubility
DMSO : 6 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=CC=C3)=O)=C1C)OCC
Molecular Formula
C18H18N2O3
Molecular Weight
310.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity towardparticular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41 (14) :2588-603.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

Chemical Information

Vegf receptor 2 kinase inhibitor I
CAS Number15966-93-5
PubChem CID6419834
IUPAC Nameethyl 2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
Molecular FormulaC18H18N2O3
Molecular Weight310.3
XLogP2.7
Topological Polar Surface Area71.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity516
SMILES
CCOC(=O)C1=C(NC(=C1C)/C=C\2/C3=CC=CC=C3NC2=O)C
InChI
InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
InChIKey
PMUJUSJUVIXDQC-LCYFTJDESA-N
Chemical Structure
2D Structure
2D structure of Vegf receptor 2 kinase inhibitor I
CAS: 15966-93-5
CID: 6419834
Formula: C18H18N2O3
MW: 310.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight310.3
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass310.13174244
Monoisotopic Mass310.13174244
Topological Polar Surface Area71.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity516
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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