PDGFRα kinase inhibitor 2

PDGFRα kinase inhibitor 2

• CAS Number: 404844-11-7
• UNSPSC Description: PDGFRα kinase inhibitor 2 (compound 1), an Imatinib (HY-15463) analogue, is a covalent and irreversible kinase inhibitor with IC50s of 6.95 μM, 2.45 μM, 1.39 μM for ABL1 wt, KIT wt, PDGFRR wt[1].
• Target Antigen: Bcr-Abl; c-Kit; PDGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pdgfrα-kinase-inhibitor-2.html
• Purity: 98.95
• Solubility: DMSO : 17.5 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=CC=C(CCl)C=C1)NC2=CC=C(C)C(NC3=NC(C4=CN=CC=C4)=CC=N3)=C2
• Molecular Weight: 429.90
• References & Citations: [1]Emeline Leproult, et al. Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported