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Isoliquiritigenin

CAT: 0804-HY-N0102-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0102-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
CAS Number
961-29-5
Product Name Alternative
GU17; ISL; Isoliquiritigen; SJ000286237
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aldose Reductase; Apoptosis; Autophagy; Influenza Virus
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Isoliquiritigenin.html
Purity
98.17
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
Molecular Formula
C15H12O4
Molecular Weight
256.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56 (3) :254-8.|[2]Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30 (1) :145-9.|[3]Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890.|[4]Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl) . 2012 Nov;90 (11) :1311-9.|[5]Traboulsi H, et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob Agents Chemother. 2015 Oct;59 (10) :6317-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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