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Atumelnant

CAT: 0804-HY-158081-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158081-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2392970-97-5
UNSPSC Description
CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with KB values of 0.34 nM and 0.23 nM, respsectively[1].
Target Antigen
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/crn04894.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C[C@H](N(C2=C(N=C(C3=C(C=CC=C3)OCC)C=C2)C(N[C@H]4C5CCN(CC5)C4)=O)CC1)CC)C6(CCC6)C(F)(F)F
Molecular Weight
613.71
References & Citations
[1]Kim SH, et al. Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485.
Shipping Conditions
Room Temperature
Clinical Information
Phase 2

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CatalogName
GTR19235990-01Atumelnant

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