IFN-alpha/beta R2, Cynomolgus (HEK293, His)

IFN-alpha/beta R2, Cynomolgus (HEK293, His)

• UNSPSC Description: IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs[1]. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins[2]. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFN-alpha/beta R2 Protein, Cynomolgus (HEK293, His) is a recombinant biotinylated cynomolgus IFN-alpha/beta R2 (M1-K243) with C-terminal His tag, which is produced in HEK293 cells.
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/ifn-alpha-beta-r2-protein-cynomolgus-hek293-his.html
• Purity: 98.0
• Smiles: ISHDLPDYTS ESCTFKISLR NFRSILSWEL KNHSIVATHY KLLYTIMSKP EDLKIVKNCA NTTRSFCDLT DEWRSIHEAY VTSLEGFSGN TTLFNCSHNF WLDIDMSFEP PEFEIVGFTN HINVIVKFPS IVEEELQFDL SLVIEEQSEG IVKKHKPTIK GNMSGNFTYI IDKLIPNTNY CVSVYFDHND EQAVIKSPLK CTLLQPGQES ESAESAK
• Molecular Weight: Approximately 40-55 kDa due to the glycosylation
• References & Citations: [1]Zanin N, et al. Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Front Immunol. 2021 Jan 20;11:615603.|[2]Shemesh M, et al. IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Sci Signal. 2021 Nov 23;14(710):eabe4627. |[3]Jun Zou, et al. Chapter 7 - Antiviral Immunity: Origin and Evolution in Vertebrates. The Evolution of the Immune System. 2016,Pages 173-204.|[4]Pogue SL, et al. The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res. 2004 Feb;24(2):131-9.|[5]Duncan CJ, et al. Human IFNAR2 deficiency: Lessons for antiviral immunity. Sci Transl Med. 2015 Sep 30;7(307):307ra154.|[6]Hurtado-Guerrero I, et al. Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-β Mediation. J Clin Med. 2020 Mar 31;9(4):959.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years