Arg-Gly-Asp-Ser

Arg-Gly-Asp-Ser

• Product Name Alternative: RGDS peptide; Fibronectin tetrapeptide
• CAS Number: 91037-65-9
• UNSPSC Description: Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
• Target Antigen: Integrin
• Type: Peptides
• Related Pathways: Cytoskeleton
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/Arg-Gly-Asp-Ser.html
• Purity: 99.93
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ 25 mg/mL
• Smiles: O=C(N[C@@H](CO)C(O)=O)[C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O
• Molecular Weight: 433.42
• References & Citations: [1]Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9.|[2]Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18.|[3]Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15.|[4]Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported