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C21

CAT: 0804-HY-P1182Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-P1182Size:Inquire
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CAS Number
[1229236-78-5]
UNSPSC Description
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1].
Target Antigen
Histone Methyltransferase
Type
Peptides
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c21.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](C)NC(CNC(CNC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC(CNC([C@H](CCCCN)NC(CNC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCNC(CCl)=N)NC(CNC([C@H](CO)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O
Molecular Weight
2166.92
References & Citations
[1]Obiamaka Obianyo, et al. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14;11(9):1219-23.
Shipping Conditions
Room temperature
Clinical Information
Phase 3

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