C21

• UNSPSC Description:

  C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1].

• Target Antigen:

  Histone Methyltransferase

• Type:

  Peptides

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c21.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](C)NC(CNC(CNC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC(CNC([C@H](CCCCN)NC(CNC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCNC(CCl)=N)NC(CNC([C@H](CO)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O

• Molecular Weight:

  2166.92

• References & Citations:

  [1]Obiamaka Obianyo, et al. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14;11(9):1219-23.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 3

• CAS Number:

  [1229236-78-5]